Hirosaki University Technology: Triptansulin Derivative: K23-010
Fluorescent dyes that can be widely used from biological systems to metals.
Triptanslin is known as an antibacterial agent extracted from the plant indigo. The inventors of this invention chemically synthesized triptanslin derivatives that cannot be obtained from natural sources and were investigating the structure-activity relationship regarding antibacterial properties when they discovered that introducing an amino group at the 2-position of triptanslin resulted in strong fluorescence. This invention relates to fluorescent reagents of triptanslin. **Characteristics of Triptanslin Derivatives** - 2-Aminotryptanslin (T2NH2) can be excited at wavelengths in the visible light range with minimal damage to cells and changes its fluorescence color in response to the surrounding environment (polarity). Additionally, through fluorescence resonance energy transfer (FRET) with pyrene, red fluorescence derived from T2NH2 is observed when FRET is on, but in the presence of certain metal ions such as mercury, it becomes FRET-off and changes to blue fluorescence derived from pyrene. - 2-Hydroxytriptanslin emits light in the wavelength range of the biological window (650–900 nm), which has excellent biocompatibility and is less affected by proton dissociation in the excited state and by the absorption of water or biological substances.
- Company：Tohoku Techno Arch Co., Ltd.
- Price：Other
